Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor

Table 1

List of nsSNPs that were predicted by PROVEAN to have functional significance.

SNP_ID	Mutation	PROVEAN results	PROVEAN score
rs1799816	V1012M	Neutral	−2.418
rs52836744	G58R	Deleterious	−6.762
rs121913144	R1027
rs121913145	H236R	Deleterious	−5.616
rs121913156	R1201Q	Deleterious	−3.701
rs891087	D261E	Neutral	−0.116
rs2162771	P830L	Neutral	−1.576
rs13306449	Y1361C	Deleterious	−4.157
rs35045353	G811S	Neutral	−2.401
rs1051691	I448T	Deleterious	−3.774
rs1051692	Y171H	Neutral	−1.304
rs2229429	D546E	Neutral	−2.474
rs7508518	A2G	Neutral	0.465
rs52800171	W1220L	Deleterious	−11.648
rs55816055	S353P	Deleterious	−2.761
rs56395521	L1065V	Neutral	−1.133
rs72549237	V362I	Neutral	−0.211
rs76077021	R889W	Deleterious	−4.254
rs76673783	E664G	Deleterious	−5.068
rs78433961	R796S	Neutral	−0.984
rs78827745	M65K	Deleterious	−3.808
rs79312957	R413C	Deleterious	−5.623
rs113527718	S1297G	Deleterious	−2.539
rs138528064	T320M	Neutral	−1.959
rs140762552	T107M	Deleterious	−2.922
rs140852238	E51K	Deleterious	−2.545
rs141484557	G262S	Deleterious	−3.037
rs142391704	A706D	Neutral	0.622
rs142910337	D75G	Neutral	1.672
rs143523271	S748L	Neutral	−0.793
rs143919163	G192D	Neutral	−1.884
rs144029037	V900I	Neutral	−0.698
rs146588336	D946E	Neutral	−0.743
rs147671523	E517G	Deleterious	−4.293
rs148838377	P755S	Neutral	−0.076
rs149536206	H8598
rs150114699	L991I	Neutral	−1.71
rs181150880	R410Q	Neutral	−2.011
rs182552223	T858A	Deleterious	−2.612
rs183360558	D893N	Neutral	−1.752
rs185736681	R1053C	Deleterious	−5.933
rs187282966	R889Q	Neutral	−1.492
rs199580495	S1033F	Deleterious	−5.642
rs199599404	M1319I	Neutral	−1.196
rs199659271	C219R	Deleterious	−9.831
rs200059069	K411Q	Neutral	−1.21
rs200110540	V866I	Neutral	−0.134
rs200199169	P271L	Neutral	−2.315
rs200400127	A1340V	Neutral	−1.519
rs200921389	G1048D	Neutral	−1.585
rs201147780	K294R	Neutral	−0.904
rs201466857	T858M	Deleterious	−3.384
rs201506342	P1312T	Deleterious	−3.008
rs201978448	A537V	Deleterious	−3.252
rs201979105	S1221A	Deleterious	−2.698
rs202160383	R1128H	Neutral	−2.063

Premature stop codon.