Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor

Table 2

Potential effect of amino acid substitution for nsSNPs in human INSR predicted by the PolyPhen algorithm.

SNP_ID	Mutation	PolyPhen results	Score	Sensitivity	Specificity
rs1799816	V1012M	Probably damaging	0.992	0.7	0.97
rs52836744	G58R	Probably damaging	1	0	1
rs121913144	R1027
rs121913145	H236R	Probably damaging	1	0	1
rs121913156	R1201Q	Probably damaging	1	0	1
rs891087	D261E	Benign	0	1	0
rs2162771	P830L	Benign	0	1	0
rs13306449	Y1361C	Probably damaging	1	0	1
rs35045353	G811S	Benign	0.441	0.89	0.9
rs1051691	I448T	Probably damaging	0.996	0.55	0.98
rs1051692	Y171H	Benign	0.024	0.95	0.81
rs2229429	D546E	Benign	0.032	0.95	0.82
rs7508518	A2G	Benign	0	1	0
rs52800171	W1220L	Probably damaging	1	0	1
rs55816055	S353P	Possibly damaging	0.528	0.88	0.9
rs56395521	L1065V	Benign	0	1	0
rs72549237	V362I	Benign	0.003	0.98	0.44
rs76077021	R889W	Benign	0.111	0.93	0.86
rs76673783	E664G	Possibly damaging	0.592	0.87	0.91
rs78433961	R796S	Benign	0.001	0.99	0.15
rs78827745	M65K	Possibly damaging	0.934	0.8	0.94
rs79312957	R413C	Probably damaging	0.999	0.14	0.99
rs113527718	S1297G	Benign	0.004	0.97	0.59
rs138528064	T320M	Benign	0.199	0.92	0.88
rs140762552	T107M	Probably damaging	1	0	1
rs140852238	E51K	Benign	0.003	0.98	0.44
rs141484557	G262S	Possibly damaging	0.939	0.8	0.94
rs142391704	A706D	Benign	0	1	0
rs142910337	D75G	Benign	0	1	0
rs143523271	S748L	Benign	0	1	0
rs143919163	G192D	Benign	0.005	0.97	0.74
rs144029037	V900I	Benign	0.048	0.94	0.83
rs146588336	D946E
rs147671523	E517G	Possibly damaging	0.726	0.86	0.92
rs148838377	P755S	Benign	0	1	0
rs149536206	H8598
rs150114699	L991I	Benign	0.442	0.89	0.9
rs181150880	R410Q	Possibly damaging	0.935	0.8	0.94
rs182552223	T858A	Benign	0.007	0.96	0.75
rs183360558	D893N	Benign	0	1	0
rs185736681	R1053C	Benign	0.223	0.91	0.88
rs187282966	R889Q	Benign	0.252	0.91	0.88
rs199580495	S1033F	Probably damaging	0.968	0.77	0.95
rs199599404	M1319I	Benign	0.007	0.96	0.75
rs199659271	C219R	Probably damaging	1	0	1
rs200059069	K411Q	Possibly damaging	0.75	0.85	0.92
rs200110540	V866I	Benign	0	1	0
rs200199169	P271L	Benign	0	1	0
rs200400127	A1340V	Benign	0.021	0.95	0.8
rs200921389	G1048D	Benign	0.009	0.96	0.77
rs201147780	K294R	Benign	0.008	0.96	0.76
rs201466857	T858M	Probably damaging	0.994	0.69	0.97
rs201506342	P1312T	Possibly damaging	0.616	0.87	0.91
rs201978448	A537V	Benign	0.143	0.92	0.86
rs201979105	S1221A	Probably damaging	0.997	0.41	0.98
rs202160383	R1128H	Benign	0.031	0.95	0.82

remature stop codon.