Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor

Table 3

List of nsSNPs’ stability predicted by I-MUTANT.

SNP_ID	Mutation	Stability	SNP_ID	Mutation	Stability
rs1799816	V1012M	Decrease	rs141484557	G262S	Decrease
rs52836744	G58R	Decrease	rs142391704	A706D	Decrease
rs121913144	R1027		rs142910337	D75G	Decrease
rs121913145	H236R	Decrease	rs143523271	S748L	Increase
rs121913156	R1201Q	Decrease	rs143919163	G192D	Decrease
rs891087	D261E	Increase	rs144029037	V900I	Decrease
rs2162771	P830L	Decrease	rs146588336	D946E	Increase
rs13306449	Y1361C	Increase	rs147671523	E517G	Increase
rs35045353	G811S	Decrease	rs148838377	P755S	Decrease
rs1051691	I448T	Decrease	rs149536206	H8598
rs1051692	Y171H	Decrease	rs150114699	L991I	Decrease
rs2229429	D546E	Increase	rs181150880	R410Q	Decrease
rs7508518	A2G	Decrease	rs182552223	T858A	Decrease
rs52800171	W1220L	Decrease	rs183360558	D893N	Decrease
rs55816055	S353P	Increase	rs185736681	R1053C	Decrease
rs56395521	L1065V	Decrease	rs187282966	R889Q	Decrease
rs72549237	V362I	Decrease	rs199580495	S1033F	Increase
rs76077021	R889W	Decrease	rs199599404	M1319I	Decrease
rs76673783	E664G	Decrease	rs199659271	C219R	Decrease
rs78433961	R796S	Decrease	rs200059069	K411Q	Increase
rs78827745	M65K	Decrease	rs200110540	V866I	Decrease
rs79312957	R413C	Decrease	rs200199169	P271L	Decrease
rs113527718	S1297G	Decrease	rs200400127	A1340V	Decrease
rs138528064	T320M	Decrease	rs200921389	G1048D	Decrease
rs140762552	T107M	Decrease	rs201147780	K294R	Increase
rs140852238	E51K	Decrease	rs201466857	T858M	Decrease
rs201506342	P1312T	Decrease	rs201979105	S1221A	Decrease
rs201978448	A537V	Increase	rs202160383	R1128H	Decrease

Premature stop codon.