Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor

Table 4

Common amino acid change due to deleterious nsSNPs in human INSR predicted by PROVEAN and PolyPhen algorithms.

SNP_ID	Mutation	PROVEAN results	PROVEAN score	PolyPhen results	PolyPhen score
rs52836744	G58R	Deleterious	−6.762	Probably damaging	1
rs121913145	H236R	Deleterious	−5.616	Probably damaging	1
rs121913156	R1201Q	Deleterious	−3.701	Probably damaging	1
rs13306449	Y1361C	Deleterious	−4.157	Probably damaging	1
rs1051691	I448T	Deleterious	−3.774	Probably damaging	0.996
rs52800171	W1220L	Deleterious	−11.648	Probably damaging	1
rs55816055	S353P	Deleterious	−2.761	Possibly damaging	0.528
rs76673783	E664G	Deleterious	−5.068	Possibly damaging	0.592
rs78827745	M65K	Deleterious	−3.808	Possibly damaging	0.934
rs79312957	R413C	Deleterious	−5.623	Probably damaging	0.999
rs140762552	T107M	Deleterious	−2.922	Probably damaging	1
rs141484557	G262S	Deleterious	−3.037	Possibly damaging	0.939
rs147671523	E517G	Deleterious	−4.293	Possibly damaging	0.726
rs199580495	S1033F	Deleterious	−5.642	Probably damaging	0.968
rs199659271	C219R	Deleterious	−9.831	Probably damaging	1
rs201466857	T858M	Deleterious	−3.384	Probably damaging	0.994
rs201506342	P1312T	Deleterious	−3.008	Possibly damaging	0.616
rs201979105	S1221A	Deleterious	−2.698	Probably damaging	0.997