Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor

Table 5

Mapping of nsSNPs in 2HR7 and 4IBM 3D structures.

SNP_ID	Mutation	PDB residue number	Solvent accessibility	Conservation
2HR7
rs52836744	G58R	31	Intermediate 10%	5%
rs121913145	H236R	209	Intermediate 23%	10%
rs1051691	I448T	421	Buried 1%	1%
rs55816055	S353P	326	Buried 5%	3%
rs78827745	M65K	38	Buried 0%	8%
rs79312957	R413C	386	Exposed 58%	3%
rs140762552	T107M	80	Buried 2%	5%
rs141484557	G262S	235	Exposed 46%	25%
rs199659271	C219R	192	Buried 5%	11%
4IBM
rs121913156	R1201Q	1174	Intermediate 10%	0%
rs52800171	W1220L	1193	Buried 1%	0%
rs199580495	S1033F	1006	Intermediate 30%	0%
rs201979105	S1221A	1194	Buried 5%	0%