Research Article
Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor
Table 6
RMSD and total energy after energy minimization of native structures and their mutant 3D models.
| | Molecules | RMSD (Å) | Total energy after energy minimization (kJ/mol) |
| | 2HR7 native-type structure | 6.019 | −22087.6969 | | 2HR7 mutant (rs52836744) | 6.007 | −21968.7347 | | 2HR7 mutant (rs121913145) | 5.985 | −21815.0585 | | 2HR7 mutant (rs1051691) | 5.997 | −22160.7304 | | 2HR7 mutant (rs55816055) | 5.957 | −21903.7516 | | 2HR7 mutant (rs78827745) | 5.991 | −21816.4353 | | 2HR7 mutant (rs79312957) | 6.025 | −21962.4576 | | 2HR7 mutant (rs140762552) | 5.992 | −21823.0448 | | 2HR7 mutant (rs141484557) | 5.995 | −22076.7362 | | 2HR7 mutant (rs199659271) | 5.98 | −21736.5417 |
| | 4IBM native-type structure | 0.404 | −13041.4646 | | 4IBM mutant (rs121913156) | 0.436 | −13091.3512 | | 4IBM mutant (rs52800171) | 0.39 | −12830.5659 | | 4IBM mutant (rs199580495) | 0.402 | −11940.1628 | | 4IBM mutant (rs201979105) | 0.376 | −13076.6808 |
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