Research Article
Computational Analysis of Damaging Single-Nucleotide Polymorphisms and Their Structural and Functional Impact on the Insulin Receptor
Table 7
Protein stability upon mutation.
| | Molecules | Mutation | PDB residue number | RSA (%) | Predicted ΔΔ | Outcome |
| | 2HR7 native-type structure | | | | | | | 2HR7 mutant (rs52836744) | G58R | 31 | 33.2 | −1.11 | Destabilizing | | 2HR7 mutant (rs121913145) | H236R | 209 | 30.5 | −0.248 | Destabilizing | | 2HR7 mutant (rs1051691) | I448T | 421 | 0 | −2.403 | Highly Destabilizing | | 2HR7 mutant (rs55816055) | S353P | 326 | 15.5 | −0.339 | Destabilizing | | 2HR7 mutant (rs78827745) | M65K | 38 | 0 | −1.568 | Destabilizing | | 2HR7 mutant (rs79312957) | R413C | 386 | 70.2 | −0.931 | Destabilizing | | 2HR7 mutant (rs140762552) | T107M | 80 | 2.3 | −0.387 | Destabilizing | | 2HR7 mutant (rs141484557) | G262S | 235 | 70.3 | −0.775 | Destabilizing | | 2HR7 mutant (rs199659271) | C219R | 192 | 3.2 | −0.039 | Destabilizing | | 4IBM native-type structure | | | | | | | 4IBM mutant (rs121913156) | R1201Q | 1174 | 11.5 | −1.347 | Destabilizing | | 4IBM mutant (rs52800171) | W1220L | 1193 | 2.1 | −3.223 | Highly Destabilizing | | 4IBM mutant (rs199580495) | S1033F | 1006 | 16.7 | −0.888 | Destabilizing | | 4IBM mutant (rs201979105) | S1221A | 1194 | 9.5 | −1.858 | Destabilizing |
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