Effects of Berberine on NLRP3 and IL-1β Expressions in Monocytic THP-1 Cells with Monosodium Urate Crystals-Induced Inflammation

Figure 5

NLRP3 and IL-1β signalling in gout. Intracellular monosodium urate crystals are recognized by NLRP3 inflammasome, leading to oligomerization of NLRP3 and cleavage of procaspase-1 to caspase-1. Further, caspase-1 cleaves inactive pro-IL-1β to produce active IL-1β. NLRP3, domain present in neuronal apoptosis inhibitor protein major histocompatibility complex class II transactivator, leucine rich repeat, and pyrin domains-containing protein 3; TLR, Toll-like receptor; ASC, apoptosis-associated speck-like protein containing a caspase-recruitment domain [CARD]; NLR, NOD-like receptor; PYD, pyrin domain; LRR, leucine rich repeat; NACHT, domain present in neuronal apoptosis inhibitor protein major histocompatibility complex class II transactivator; NF-κB, nuclear factor-κB.