Effect of Oral Coadministration of Ascorbic Acid with Ling Zhi Preparation on Pharmacokinetics of Ganoderic Acid A in Healthy Male Subjects: A Randomized Crossover Study

Table 1

Pharmacokinetic parameters of ganoderic acid A following a single oral dose of 3,000 mg of MG2FB-WE alone (Ling Zhi phase) and in combination with 2,500 mg of ascorbic acid (Ling Zhi coadministered with ascorbic acid phase) in healthy male subjects.

Pharmacokinetic parameter	Ling Zhi phase	Ling Zhi coadministered with ascorbic acid phase	value
(ng/mL)	2.24 ± 1.31	2.39 ± 0.99	0.41
(h)	0.54 ± 0.10	0.44 ± 0.19	0.10
(ng⋅h/mL)	1.93 ± 0.96	2.04 ± 0.74	0.53
(ng⋅h/mL)	2.71 ± 1.09	2.82 ± 0.88	0.79
(h)	0.66 ± 0.33	0.66 ± 0.30	0.86

Data represent mean ± standard deviation (SD). = maximum plasma concentration. = time taken to reach . = area under the concentration-time curve from time zero to the last measurable sampling time point. = area under the concentration-time curve from time zero to time infinity. = elimination half-life. Wilcoxon signed-rank test.