Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation
Table 4
Biochemical measurements and comparisons for ROSC subjects.
Parameter
All subjects
Group C
Group E
p value
()
()
()
Mean (SD)
Mean (SD)
Mean (SD)
Creatinine (mg/dL)
Baseline
0.58 (0.088)
0.58 (0.109)
0.59 (0.083)
0.761
2 hours
0.70 (0.081)
0.76 (0.054)
0.67 (0.078)
0.048
4 hours
0.78 (0.065)
0.84 (0.054)
0.75 (0.052)
0.018
6 hours
0.86 (0.051)
0.86 (0.054)
0.85 (0.052)
0.843
24 hours
1.93 (0.614)
2.76 (0.054)
1.51 (0.087)
0.002
48 hours
3.44 (1.053)
5.27 (0.152)
2.89 (0.166)
0.010
Mean
1.43 (0.372)
1.77 (0.462)
1.28 (0.196)
0.014
NGAL (ng/mL)
Baseline
133.29 (15.893)
129.01 (16.686)
135.25 (15.941)
0.394
2 hours
596.89 (104.449)
743.47 (24.163)
530.26 (22.464)
0.002
4 hours
524.25 (92.649)
653.77 (15.744)
465.38 (24.026)
0.002
6 hours
439.83 (130.717)
624.03 (8.372)
356.10 (30.400)
0.002
24 hours
373.33 (160.136)
591.57 (6.239)
264.22 (13.568)
0.002
48 hours
294.61 (160.889)
576.43 (12.360)
210.06 (7.952)
0.011
Mean
457.53 (132.065)
643.39 (11.222)
373.06 (31.474)
<0.001
L-FABP (ng/mL)
Baseline
1.40 (0.188)
1.45 (0.222)
1.38 (0.177)
0.954
2 hours
1.91 (0.158)
2.11 (0.008)
1.82 (0.101)
0.002
4 hours
2.52 (0.256)
2.88 (0.033)
2.35 (0.034)
0.002
6 hours
2.73 (0.277)
3.10 (0.003)
2.56 (0.113)
0.002
24 hours
2.41 (0.229)
2.72 (0.064)
2.26 (0.029)
0.002
48 hours
2.22 (0.182)
2.54 (0.035)
2.12 (0.018)
0.011
Mean
2.37 (0.223)
2.68 (0.022)
2.22 (0.047)
<0.001
IL-18 (ng/mL)
Baseline
0.09 (0.006)
0.09 (0.006)
0.09 (0.006)
0.908
2 hours
0.10 (0.005)
0.10 (0.002)
0.09 (0.002)
0.001
4 hours
0.11 (0.003)
0.11 (0.002)
0.10 (0.001)
0.002
6 hours
0.12 (0.014)
0.14 (0.002)
0.11 (0.002)
0.002
24 hours
0.16 (0.039)
0.21 (0.003)
0.13 (0.002)
0.002
48 hours
0.12 (0.018)
0.15 (0.002)
0.11 (0.002)
0.010
Mean
0.12 (0.016)
0.14 (0.003)
0.11 (0.002)
<0.001
ROSC = return of spontaneous circulation. Comparisons at distinct time-point between groups utilize Wilcoxon-Mann–Whitney nonparametric test for independent samples; comparisons regarding overall (mean) measurements utilize clustered regression models for longitudinal data, including all measurements after baseline (2–48 hours). Mean measurements refer to all time-points summed (2–48 hours), apart from baseline values.
