Review Article

Preoperative Chemotherapy for Gastric Cancer: Personal Interventions and Precision Medicine

Table 2

Preoperative chemoradiotherapy.

ReferencePatients ()treatmentSurgery (%)R0 resection (%)PCR (%)Survival rate (%) or median survival (mo)

Lowy et al. [21]245-FU + 45  EBRT837511NS
Wydmański et al. [22]405-FU + LV + 45 Gy EBRT80751863% (2 years)
Allal et al. [23]195-FU + LV + C + 38.4 Gy100NS535% (5 years)
Ajani et al. [24]345-FU, LV, C + 45 Gy EBRT, 5-FU85703033.7 months
Ajani et al. [25]415-FU, C, P + 45 Gy EBRT, 5-FU, P987820NS
Ajani et al. [26]495-FU, LV, C + 45 Gy EBRT, 5-FU, P83772623.2 months
Stahl et al. [27]1265-FU, LV, C + surgery versus 5-FU, LV, C + 30 Gy, C, etoposide + surgery88 versus 8269 versus 722.0 versus 15.627.7 versus 47.4 (3 years)
Inoue et al. [29]12S-1, 50 Gy EBRT100921758.3 (3 years)
Lee et al. [30]12S-1,oxaliplaitin, 41.4 Gy EBRT100928NS
Trip et al. [31]25Carboplatin, P + 45 Gy EBRT967216NS
van Hagen et al. [32]366Carboplatin, P, 41.4 Gy EBRT + surgery versus surgery alone94 versus 9992 versus 6929 versus 4949, 4 mos versus 24.0 mos

PCR: pathologic complete response; EBRT: external beam radiotherapy; NS: not stated; 5-FU: fluorouracil; LV: leucovorin; C: cisplatin; P: paclitaxel.