High Glucose-Induced PC12 Cell Death by Increasing Glutamate Production and Decreasing Methyl Group Metabolism

<div>Representative 600 MHz 1D <sup>1</sup>H NMR spectra obtained from intracellular extracts in the control (a) and HG (b) groups. The abbreviation of metabolites: NAG: N-acetylglutamate; SucA: succinylacetone; Glu: glutamate; Suc: succinate; Gln: glutamine; DMA: dimethylamine; DMG: dimethylglycine; PCre: creatine phosphate; Cre: creatine; PheA: phenylalanine; mIns: myoinositol; 3-MetH: 3-methylhistidine.</div>

BioMed Research International

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Figure 3

Figure 3: High Glucose-Induced PC12 Cell Death by Increasing Glutamate Production and Decreasing Methyl Group Metabolism 