High Mobility Group Box1 Protein Is Involved in Endoplasmic Reticulum Stress Induced by Clostridium difficile Toxin A

Figure 5

Glycyrrhizin reduces HMGB1-induced apoptotic ER stress. CT26 cells were pretreated with glycyrrhizin 30 min before HMGB1 exposure. And then CT26 cells were treated by HMGB1 for 12 h and collected for analysis. The proteins levels change of CHOP and Bcl₂ were examined by western blotting. (a) Glycyrrhizin prevented HMGB1-induced apoptotic ER stress. (b) Glycyrrhizin reduced TcdA-induced apoptotic ER stress. Actin was used as the loading control. Data represent the mean of three independent experiments. .

(a)

(b)