Integrated Analysis of DNA Methylation and mRNA Expression Profiles Data to Identify Key Genes in Lung Adenocarcinoma

Table 1

The GO functions, KEGG pathways, and DO terms separately enriched for upregulated and downregulated genes. (a) The top 5 GO functions enriched for upregulated genes. (b) The KEGG pathways enriched for upregulated genes. (c) The DO terms enriched for upregulated genes. (d) The top 5 GO functions enriched for downregulated genes.

(a)

Category	ID	Description	Count	Gene symbol	value
BP	GO:0044243	Multicellular organismal catabolic process	15	ACE2, COL10A1, COL11A1
BP	GO:0030574	Collagen catabolic process	14	FAP, MMP1, MMP10
BP	GO:1903047	Mitotic cell cycle process	41	ANLN, AURKB, BUB1
BP	GO:0044259	Multicellular organismal macromolecule metabolic process	15	ACE2, COL10A1, COL11A1
BP	GO:0007067	Mitotic nuclear division	22	ANLN, AURKB, CDC20
CC	GO:0005576	Extracellular region	122	ACE2, ACOT11, ACY3
CC	GO:0005615	Extracellular space	46	ACE2, AGR2, BPIFA1	0.002024

(b)

ID	Description	Count	Gene symbol	value
hsa04974	Protein digestion and absorption	11	ACE2, COL10A1, COL11A1	0.001244
hsa04110	Cell cycle	11	CDC20, MAD2L1, CCNB2	0.026338

(c)

DOID	Description	Count	Gene symbol	Adjust. value
DOID:0050687	Cell type cancer	64	AURKB, MAD2L1, ASPM
DOID:2994	Germ cell cancer	41	AURKB, MAD2L1, CA9	0.001326
DOID:4766	Embryoma	38	AURKB, BUB1, MAD2L1	0.008727
DOID:688	Embryonal cancer	38	AURKB, MAD2L1, CA9	0.009481

(d)

Category	ID	Description	Count	Gene symbol	value
BP	GO:0044699	Single-organism process	296	AADAC, ABCB1, ABCG2
BP	GO:0044707	Single-multicellular organism process	150	WNT3A, ACVRL1, ADCY4
BP	GO:0003013	Circulatory system process	24	ACVRL1, ADRA1A, ADRB1
BP	GO:0032501	Multicellular organismal process	152	WNT3A, ACVRL1, ADCY4	0.001393
BP	GO:0008015	Blood circulation	23	ACVRL1, ADRA1A, ADRB1	0.001693
CC	GO:0031226	Intrinsic component of plasma membrane	72	ACVRL1, ADRA1A, ADRB1
CC	GO:0005886	Plasma membrane	139	WNT3A, ADCY8, ADGRB3
CC	GO:0071944	Cell periphery	140	WNT3A, ANXA8, AQP10
CC	GO:0044459	Plasma membrane part	86	AGER, AGTR1, AQP10
CC	GO:0005887	Integral component of plasma membrane	68	FZD4, GHR, GP9