The Influence of Bone Marrow-Secreted IL-10 in a Mouse Model of Cerulein-Induced Pancreatic Fibrosis

Figure 5

((a)–(h)) Sirius red staining of the pancreas from cerulein treated female mice that received either a wild-type male bone marrow or an IL-10 knock out male bone marrow transplant. (a) and (b) show normal collagen deposition between lobules after cerulein injection for 1 day. (c)–(h) show progressive collagen deposition with time. (i) Sirius red positive areas to the total area. Only in the recovery group is collagen deposition in the IL-10 knock out group significantly higher than that in the wild-type bone marrow group (p < 0.01).

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(i) Collagen deposition