Research Article
Circulating Betatrophin Is Increased in Patients with Overt and Subclinical Hypothyroidism
Table 1
Characteristics of the study population.
| | | OH | SCH | Isolated Ab | HC | P value |
| | Sex (F/M) | 31 (25/6) | 30 (26/4) | 30 (25/5) | 31 (25/6) | 0.910 | | Age (years) | 49.0 ± 14.1 | 51.8 ± 18.2 | 48.0 ± 13.2 | 52.0 ± 11.1 | 0.617 | | BMI (kg/m2) | 20.3 ± 1.3 | 20.1 ± 1.5 | 20.3 ± 1.6 | 20.0 ± 1.4 | 0.850 | | SBP (mmHg) | 121.6 ± 6.1 | 124.0 ± 6.1 | 124.2 ± 5.7 | 121.5 ± 7.7 | 0.192 | | DBP (mmHg) | 72.5 ± 8.3 | 71.8 ± 6.7 | 72.0 ± 4.3 | 70.0 ± 5.0 | 0.429 | | TSH (mIU/L) | 34.0 (19.3–57.2) | 15.5 (10.9–40.4) | 3.0 (2.2–3.8) | 1.8 (1.3–3.4) | <0.001 | | FT4 (pmol/L) | 6.7 (5.7–8.2) | 13.3 (11.5–13.6) | 13.4 (12.4–14.8) | 13.5 (12.9–14.7) | <0.001 | | FT3 (pmol/L) | 3.0 (2.2–3.3) | 4.0 (3.6–4.1) | 4.0 (3.8–4.3) | 4.3 (3.8–4.7) | <0.001 | | TPOAb (IU/mL) | 1000.0 (500.0–1000.0) | 771.3 (581.7–1000.0) | 1000.0 (781.2–1000.0) | 0.4 (0.2–1.2) | <0.001 | | TgAb (IU/mL) | 379.9 (75.2–1000.0) | 169.2 (46.6–1000.0) | 110.8 (55.3–521.5) | 1.1 (0.9–1.6) | <0.001 | | GGT (IU/L) | 18 (12–31) | 17 (13–25) | 16 (10–26) | 15 (10–25) | 0.395 | | AST (IU/L) | 18 (16–22) | 18 (15–21) | 17 (14–19) | 18 (15–23) | 0.631 | | ALT (IU/L) | 15 (11–20) | 14 (11–40) | 15 (10–17) | 16 (10–21) | 0.657 | | HDL-C (mmol/L) | 1.4 (1.2–1.7) | 1.2 (1.0–1.6) | 1.3 (1.1–1.5) | 1.4 (1.2–1.9) | 0.154 | | LDL-C (mmol/L) | 3.0 (2.5–3.4) | 2.5 (2.2–3.3) | 2.3 (1.7–3.3) | 2.4 (1.6–2.8) | 0.005 | | TG (mmol/L) | 2.2 (1.2–2.6) | 1.7 (1.4–2.4) | 1.3 (1.1–2.6) | 1.3 (0.9–1.8) | 0.024 | | TC (mmol/L) | 4.6 (3.7–5.6) | 4.2 (2.9–5.8) | 4.3 (3.9–5.3) | 3.8 (3.4–4.8) | 0.083 | | Betatrophin (pg/m) | 548.9 (287.0–764.2) | 443.3 (250.5–616.6) | 237.3 (176.7–323.8) | 238.0 (184.3–421.4) | <0.001 |
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F: female; M: male.
Results are shown as arithmetic mean ± S.D.
Results are shown as median with interquartile range.
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