The Association between VDR Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis

Table 3

Meta-analysis of VDR gene FokI polymorphism and DR susceptibility.

Genetic model	Pooled method		(%)	OR	95% CI	(FDR)
f versus F
Overall	Fixed-effect	0.100	45.8	1.612	1.354~1.921	<0.001
Caucasian	Fixed-effect	0.320	12.3	1.293	1.013~1.650	0.056
Asian	Fixed-effect	0.836	0.0	2.049	1.591~2.638	<0.001
DM1	Fixed-effect	0.206	37.6	1.418	1.021~1.969	0.057
DM2	Random-effect	0.079	55.9	1.731	1.261~2.377	0.002
ff + Ff versus FF
Overall	Fixed-effect	0.103	45.3	1.988	1.481~2.668	<0.001
Caucasian	Fixed-effect	0.333	9.2	1.475	1.016~2.142	0.055
Asian	Fixed-effect	0.634	0.0	3.254	1.995~5.308	<0.001
DM1	Fixed-effect	0.183	43.7	1.630	1.012~2.626	0.056
DM2	Random-effect	0.091	53.6	2.396	1.346~4.263	0.005
ff versus Ff + FF
Overall	Fixed-effect	0.317	15.1	1.889	1.424~2.505	<0.001
Caucasian	Fixed-effect	0.676	0.0	1.327	0.857~2.055	0.204
Asian	Fixed-effect	0.656	0.0	2.445	1.680~3.559	<0.001
DM1	Fixed-effect	0.503	0.0	1.514	0.809~2.832	0.205
DM2	Fixed-effect	0.183	38.2	2.001	1.459~2.746	<0.001
ff versus FF
Overall	Random-effect	0.053	54.3	2.674	1.493~4.790	0.002
Caucasian	Fixed-effect	0.410	0.0	1.616	0.974~2.683	0.074
Asian	Fixed-effect	0.416	0.0	4.723	2.702~8.253	<0.001
DM1	Fixed-effect	0.248	25.1	1.893	0.948~3.777	0.078
DM2	Random-effect	0.036	64.8	3.304	1.520~7.185	0.005