Meta-Analysis of the Association between Vitiligo and Human Leukocyte Antigen-A
Table 2
Association between vitiligo and 33 human leukocyte antigen- (HLA-) A alleles.
Allele
Patients% ()
Controls% ()
OR (95% CI)/article number
A01
28.20 (249/883)
28.65 (677/2363)
0.95r (0.66, 1.35)/11
0.761
A02
26.94 (761/2825)
34.25 (1710/4992)
1.52r (1.21, 1.90)/15
<0.001
A03
19.70 (143/726)
14.30 (378/2643)
1.45r (0.99, 2.13)/11
0.056
A04
3.85 (2/52)
3.00 (3/100)
1.29 (0.21, 7.99)/1
0.782
A09
20.07 (108/538)
26.25 (461/1756)
0.70 (0.54, 0.90)/8
0.005
A10
10.56 (47/445)
12.79 (175/1368)
1.11r (0.51, 2.41)/7
0.786
A11
15.80 (100/633)
14.41 (325/2255)
0.87 (0.66, 1.14)/10
0.306
A19
22.50 (18/80)
43.75 (35/80)
0.19r (0.02, 2.02)/2
0.170
A23
5.47 (11/201)
7.22 (32/443)
0.76 (0.38, 1.53)/3
0.436
A24
21.67 (52/240)
40.53 (400/987)
0.89r (0.36, 2.21)/4
0.800
A25
11.83 (42/355)
5.71 (34/595)
1.29r (0.26, 6.43)/3
0.756
A26
8.05 (176/2185)
13.42 (342/2549)
0.79r (0.53, 1.19)/6
0.265
A28
7.89 (31/393)
8.60 (109/1268)
0.74 (0.46, 1.17)/6
0.192
A29
6.13 (22/359)
7.90 (115/1455)
0.78 (0.49, 1.27)/6
0.320
A30
12.37 (74/598)
6.92 (119/1720)
1.83r (0.88, 3.81)/8
0.107
A31
3.88 (84/2166)
6.54 (189/2892)
1.33r (0.61, 2.90)/6
0.479
A32
6.41 (15/234)
8.24 (73/886)
0.78 (0.43, 1.40)/4
0.400
A33
22.16 (430/1940)
8.78 (184/2096)
2.23 (1.84, 2.70)/4
<0.001
A34
0.00 (0/116)
3.29 (8/243)
0.12 (0.01, 2.08)/1
0.145
A36
0.58 (2/343)
2.24 (12/535)
0.43r (0.04, 5.02)/3
0.501
A38
0.00 (0/40)
2.50 (1/40)
0.33 (0.01, 8.22)/1
0.495
A43
31.72 (72/227)
36.64 (107/292)
0.85 (0.58, 1.24)/2
0.394
A66
2.82 (10/355)
7.73 (46/595)
0.58r (0.08, 4.25)/3
0.595
A68
14.45 (283/1959)
12.09 (212/1753)
1.12 (0.93, 1.36)/4
0.238
A69
0.00 (0/116)
0.82 (2/243)
0.41 (0.02, 8.71)/1
0.571
A80
1.28 (2/156)
1.77 (5/283)
0.52 (0.11, 2.43)/2
0.405
Aw19
0.72 (13/1806)
6.35 (90/1417)
0.11 (0.06, 0.19)/2
<0.001
Aw23
2.08 (1/48)
4.67 (5/107)
0.43 (0.05, 3.82)/1
0.452
Aw24
0.00 (0/48)
2.80 (3/107)
0.31 (0.02, 6.08)/1
0.439
Aw30
20.83 (10/48)
28.04 (30/107)
0.68 (0.30, 1.52)/1
0.345
Aw31
16.67 (8/48)
4.67 (5/107)
4.08 (1.26, 13.22)/1
0.019
Aw32
4.17 (2/48)
8.41 (9/107)
0.47 (0.10, 2.28)/1
0.351
Aw33
9.20 (8/87)
12.29 (80/651)
1.03 (0.46, 2.30)/1
0.944
: total number of subjects, : positive number of subjects, OR: odds ratio, CI: confidence interval, article number: total number of the articles relevant to the association between vitiligo and HLA-A alleles, r: random effects model, and the others: fixed effects model.
