Meta-Analysis of the Association between Vitiligo and Human Leukocyte Antigen-A
Table 3
Association between vitiligo and human leukocyte antigen- (HLA-) A alleles in terms of ethnicity.
Ethnicity
Allele
Patients% ()
Controls% ()
OR (95% CI)/article number
Asian
A01
32.54 (165/507)
34.04 (241/708)
0.91 (0.66, 1.26)/6
0.574
A02
21.45 (515/2401)
26.31 (693/2634)
1.24r (0.93, 1.67)/9
0.147
A03
16.71 (60/359)
5.00 (50/1000)
2.46r (1.11, 5.45)/6
0.026
A04
3.85 (2/52)
3.00 (3/100)
1.29 (0.21, 7.99)/1
0.782
A09
18.82 (54/287)
24.72 (88/356)
0.60 (0.40, 0.89)/4
0.010
A10
10.45 (30/287)
3.65 (13/356)
2.73 (1.40, 5.35)/4
0.003
A11
22.84 (82/359)
20.10 (201/1000)
0.99 (0.71, 1.38)/6
0.960
A19
22.50 (18/80)
43.75 (35/80)
0.19r (0.02, 2.02)/2
0.170
A23
2.35 (2/85)
4.00 (8/200)
0.72 (0.17, 3.11)/2
0.662
A24
25.00 (31/124)
48.12 (358/744)
0.79r (0.17, 3.76)/3
0.767
A25
17.57 (42/239)
7.10 (25/352)
2.65 (1.56, 4.51)/2
<0.001
A26
8.07 (167/2069)
13.96 (322/2306)
0.76r (0.47, 1.24)/5
0.274
A28
7.66 (18/235)
11.33 (29/256)
0.43r (0.08, 2.20)/3
0.311
A29
2.35 (2/85)
5.00 (10/200)
0.45 (0.10, 2.08)/2
0.307
A30
13.20 (47/356)
6.50 (42/646)
2.18r (0.85, 5.61)/5
0.107
A31
3.72 (75/2017)
6.53 (144/2206)
1.79r (0.55, 5.85)/4
0.335
A32
8.24 (7/85)
9.00 (18/200)
0.90 (0.36, 2.23)/2
0.813
A33
23.56 (422/1791)
11.28 (159/1410)
2.32 (1.90, 2.83)/2
<0.001
A36
0.89 (2/227)
2.74 (8/292)
0.61r (0.01, 40.53)/2
0.818
A38
0.00 (0/40)
2.50 (1/40)
0.33 (0.01, 8.22)/1
0.495
A43
31.72 (72/227)
36.64 (107/292)
0.85 (0.58, 1.24)/2
0.394
A66
2.93 (7/239)
12.50 (44/352)
0.20 (0.09, 0.45)/2
<0.001
A68
14.38 (265/1843)
12.58 (190/1510)
1.08 (0.88, 1.32)/3
0.476
A80
5.00 (2/40)
10.00 (4/40)
0.47 (0.08, 2.75)/1
0.405
Aw19
0.74 (13/1758)
6.79 (89/1310)
0.10 (0.06, 0.18)/1
<0.001
Aw33
12.82 (5/39)
13.79 (75/544)
0.92 (0.35, 2.43)/1
0.866
European
A01
16.30 (22/135)
27.88 (235/843)
0.46 (0.28, 0.74)/2
0.002
A02
62.84 (115/183)
41.01 (757/1546)
1.80 (1.30, 2.48)/3
<0.001
A03
25.40 (32/126)
20.58 (171/831)
1.23 (0.79, 1.92)/2
0.359
A09
20.63 (26/126)
24.43 (203/831)
0.79 (0.50, 1.26)/2
0.321
A10
9.09 (3/33)
13.09 (58/443)
0.66 (0.20, 2.25)/1
0.510
A11
15.15 (5/33)
9.71 (43/443)
1.66 (0.61, 4.53)/1
0.321
A28
9.09 (3/33)
5.42 (24/443)
1.75 (0.50, 6.13)/1
0.385
A29
9.09 (3/33)
7.45 (33/443)
1.24 (0.36, 4.29)/1
0.731
A30
9.52 (12/126)
4.81 (40/831)
1.70r (0.16, 18.02)/2
0.660
A31
9.09 (3/33)
4.97 (22/443)
1.91 (0.54, 6.76)/1
0.313
A32
12.12 (4/33)
7.90 (35/443)
1.61 (0.53, 4.83)/1
0.398
A33
6.06 (2/33)
2.26 (10/443)
2.79 (0.59, 13.31)/1
0.197
American
A01
24.39 (40/164)
16.29 (57/350)
1.91r (0.66, 5.53)/2
0.230
A02
60.98 (100/164)
36.86 (129/350)
2.73 (1.85, 4.03)/2
<0.001
A03
18.90 (31/164)
22.29 (78/350)
0.81 (0.51, 1.29)/2
0.373
A09
20.83 (10/48)
18.69 (20/107)
1.14 (0.49, 2.68)/1
0.775
A10
8.33 (4/48)
27.10 (29/107)
0.24 (0.08, 0.74)/1
0.013
A11
6.71 (11/164)
10.29 (36/350)
0.82r (0.20, 3.32)/2
0.776
A23
7.76 (9/116)
9.88 (24/243)
0.77 (0.34, 1.71)/1
0.517
A24
18.10 (21/116)
17.28 (42/243)
1.06 (0.59, 1.89)/1
0.849
A25
0.00 (0/116)
3.70 (9/243)
0.11 (0.01, 1.84)/1
0.123
A26
7.76 (9/116)
8.23 (20/243)
0.94 (0.41, 2.13)/1
0.878
A28
6.25 (3/48)
11.21 (12/107)
0.53 (0.14, 1.96)/1
0.340
A29
6.10 (10/164)
9.43 (33/350)
0.64 (0.31, 1.31)/2
0.222
A30
12.93 (15/116)
15.23 (37/243)
0.83 (0.43, 1.58)/1
0.564
A31
5.17 (6/116)
9.47 (23/243)
0.52 (0.21, 1.32)/1
0.169
A32
3.45 (4/116)
8.23 (20/243)
0.40 (0.13, 1.19)/1
0.100
A33
5.17 (6/116)
6.17 (15/243)
0.83 (0.31, 2.20)/1
0.706
A34
0.00 (0/116)
3.29 (8/243)
0.12 (0.01, 2.08)/1
0.145
A36
0.00 (0/116)
1.65 (4/243)
0.23 (0.01, 4.28)/1
0.323
A66
2.59 (3/116)
0.82 (2/243)
3.20 (0.53, 19.41)/1
0.206
A68
15.52 (18/116)
9.05 (22/243)
1.85 (0.95, 3.59)/1
0.072
A69
0.00 (0/116)
0.82 (2/243)
0.41 (0.02, 8.71)/1
0.571
A80
0.00 (0/116)
0.41 (1/243)
0.69 (0.03, 17.16)/1
0.823
Aw19
0.00 (0/48)
0.93 (1/107)
0.73 (0.03, 18.29)/1
0.849
Aw23
2.08 (1/48)
4.67 (5/107)
0.43 (0.05, 3.82)/1
0.452
Aw24
0.00 (0/48)
2.80 (3/107)
0.31 (0.02, 6.08)/1
0.439
Aw30
20.83 (10/48)
28.04 (30/107)
0.68 (0.30, 1.52)/1
0.345
Aw31
16.67 (8/48)
4.67 (5/107)
4.08 (1.26, 13.22)/1
0.019
Aw32
4.17 (2/48)
8.41 (9/107)
0.47 (0.10, 2.28)/1
0.351
Aw33
6.25 (3/48)
4.67 (5/107)
1.36 (0.31, 5.94)/1
0.683
: total number of subjects, : positive number of subjects, OR: odds ratio, CI: confidence interval, article number: total number of the articles relevant to the association between vitiligo and HLA-A alleles, r: random effects model, and the others: fixed effects model.
