Meta-Analysis of the Association between Vitiligo and Human Leukocyte Antigen-A
Table 4
Association between vitiligo and human leukocyte antigen- (HLA-) A alleles in terms of clinical type.
Clinical type
Allele
Patients% ()
Controls% ()
OR (95% CI)/article number
Nonsegmental
A01
29.84 (94/315)
32.45 (355/1094)
0.81 (0.57, 1.14)/5
0.226
A02
23.36 (425/1819)
33.08 (1241/3751)
1.46r (1.01, 2.10)/9
0.042
A03
20.09 (85/423)
12.86 (241/1874)
1.98r (1.02, 3.81)/7
0.042
A09
21.19 (50/236)
25.84 (255/987)
0.70 (0.49, 1.00/4
0.052
A10
13.62 (29/213)
10.01 (70/699)
2.09r (0.83, 5.28)/4
0.117
A11
16.15 (42/260)
15.73 (218/1386)
0.90 (0.61, 1.34)/5
0.607
A19
22.50 (18/80)
43.75 (35/80)
0.28 (0.13, 0.63)/2
0.002
A23
5.13 (4/78)
9.88 (24/243)
0.49 (0.17, 1.47)/1
0.204
A24
25.64 (30/117)
46.25 (364/787)
0.72 (0.44, 1.17)/2
0.180
A25
19.19 (33/172)
6.46 (32/495)
1.18r (0.03, 47.18)/2
0.930
A26
7.64 (119/1558)
13.32 (313/2349)
0.91r (0.58, 1.43)/4
0.676
A28
13.29 (19/143)
7.35 (44/599)
1.00 (0.50, 1.98)/3
0.996
A29
7.21 (8/111)
8.60 (59/686)
0.75 (0.34, 1.62)/2
0.460
A30
13.87 (53/382)
7.24 (110/1520)
1.84r (0.73, 4.62)/6
0.196
A31
4.02 (64/1591)
6.66 (186/2792)
1.23r (0.54, 2.79)/5
0.626
A32
3.60 (4/111)
8.02 (55/686)
0.41r (0.01, 15.55)/2
0.628
A33
23.05 (336/1458)
9.02 (180/1996)
2.34 (1.91, 2.86)/3
<0.001
A34
0.00 (0/78)
3.29 (8/243)
0.18 (0.01, 3.09)/1
0.235
A36
0.94 (2/212)
2.24 (12/535)
0.54 (0.15, 1.94)/3
0.344
A38
0.00 (0/40)
2.50 (1/40)
0.33 (0.01, 8.22)/1
0.495
A43
25.37 (34/134)
36.64 (107/292)
0.75 (0.47, 1.22)/2
0.251
A66
3.49 (6/172)
8.89 (44/495)
0.83r (0.03, 23.79)/2
0.914
A68
16.07 (229/1425)
13.33 (207/1553)
1.21 (0.98, 1.48)/2
0.072
A69
0.00 (0/78)
0.82 (2/243)
0.62 (0.03, 12.95)/1
0.755
A80
1.69 (2/118)
1.77 (5/283)
0.56 (0.12, 2.66)/2
0.468
Aw33
12.82 (5/39)
13.79 (75/544)
0.92 (0.35, 2.43)/1
0.866
Segmental
A01
6.67 (2/30)
9.48 (11/116)
0.68 (0.14, 3.26)/1
0.631
A02
67.27 (37/55)
47.22 (102/216)
2.34 (1.25, 4.38)/2
0.008
A03
7.27 (4/55)
1.85 (4/216)
4.09 (1.08, 15.51)/2
0.038
A09
26.67 (8/30)
32.76 (38/116)
0.75 (0.30, 1.83)/1
0.523
A10
7.27 (4/55)
3.70 (8/216)
2.03 (0.59, 7.01)/2
0.261
A11
33.33 (10/30)
30.17 (35/116)
1.16 (0.49, 2.72)/1
0.738
A28
6.67 (2/30)
5.17 (6/116)
1.31 (0.25, 6.84)/1
0.749
: total number of subjects, : positive number of subjects, OR: odds ratio, CI: confidence interval, article number: total number of the articles relevant to the association between vitiligo and HLA-A alleles, r: random effects model, and the others: fixed effects model.
