Synergistic Effects of Danshen (Salvia Miltiorrhiza Radix et Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma) Combination in Inhibiting Inflammation Mediators in RAW264.7 Cells

Table 4

IC₅₀ values of the key bioactive compounds of Danshen and Sanqi in NO, TNF, and MCP-1 assay.

	DS compounds	IC50 (μM)
		NO	TNF-α	MCP-1
Relatively water-soluble components	DSS	144.10	NA	NA
	SA	90.23	NA	NA
	SB	108.30	NA	NA
Relatively lipid-soluble components	CT	116.80	1.98	11.32
	DT	4.64	24.25	13.97
	T1	5.45	7.627	NA
	TIIA	NA	NA	NA
	SQ compounds	IC50 (μM)
		NO	TNF-α	MCP-1
Relatively water-soluble components	NR1	92.05	NA	NA
	Rg1	NA	NA	NA
	Re	26.02	NA	NA
	Rb1	53.9	71.36	NA
Relatively lipid-soluble components	Rb2	134.90	28.44	NA
	Rg2	66.41	28.64	NA
	Rd	7.89	9.79	36.00

NA: the maximum inhibitory effect less than 50%.