Autophagy Promoted the Degradation of Mutant ATXN3 in Neurally Differentiated Spinocerebellar Ataxia-3 Human Induced Pluripotent Stem Cells

Figure 4

Autophagy was increased during neural differentiation and autophagy promoted the degradation of mutant ATXN3 in neurally differentiated spinocerebellar ataxia-3 human iPS cells. (a) Western blot was used to determine the levels of LC3-II and P62 in various cell types on days 3 and 14. Quantification of the band intensity is shown in the lower panel. (b) Western blot analysis was performed on days 0, 7, 14, and 21. Quantification of the band intensity is shown in the lower panel. ().