A Systematic Framework for Drug Repositioning from Integrated Omics and Drug Phenotype Profiles Using Pathway-Drug Network

Figure 1

The proposed framework for drug repositioning. The proposed framework consists of several steps. First, disease-specific pathways are identified by disease pathway enrichment of multiple expression profiles for the disease of interest. Second, the drug pathway network is constructed from the drug pathway associations obtained from the drug phenotype profiles. Once the network is constructed, initial labels are assigned using disease-specific pathways and known drugs associated with the given disease. Finally, pathway-based drug repositioning is performed using semisupervised network propagation. The identified drugs are evaluated, and the final results are obtained.