A Systematic Framework for Drug Repositioning from Integrated Omics and Drug Phenotype Profiles Using Pathway-Drug Network

Table 10

Betweenness of promising drug candidates on the validation network.

Rank	Drug name	Betweenness
1	Tamoxifen	172
2	Paclitaxel	37
3	Doxorubicin	32
4	Camptothecin	13
5	Exemestane	13
6	Fulvestrant	12
7	Methotrexate	10
8	Vinblastine	6
9	Megestrol	6
10	Aminoglutethimide	2
11	Letrozole	2
12	MS-275	2
13	GW-8510	0
14	Phenoxybenzamine	0
15	Tyrphostin_AG-825	0
16	Alsterpaullone	0
17	Celastrol	0

Known breast cancer drug. Potential drug candidate for repositioning.