A Systematic Framework for Drug Repositioning from Integrated Omics and Drug Phenotype Profiles Using Pathway-Drug Network

Table 11

PageRank of promising drug candidates on the validation network ().

Rank	Drug name	Ranking score
1	Tamoxifen	0.990
2	Doxorubicin	0.692
3	Paclitaxel	0.663
4	Methotrexate	0.373
5	Fulvestrant	0.316
6	Camptothecin	0.257
7	Letrozole	0.252
8	Vinblastine	0.235
9	Exemestane	0.176
10	Aminoglutethimide	0.108
11	Alsterpaullone	0.102
12	Megestrol	0.101
13	MS-275	0.088
14	Phenoxybenzamine	0.080
15	GW-8510	0.026
16	Celastrol	0.023
17	Tyrphostin_AG-825	0.010

Known breast cancer drug. Potential drug candidate for repositioning.