A Systematic Framework for Drug Repositioning from Integrated Omics and Drug Phenotype Profiles Using Pathway-Drug Network

Table 7

Degree centrality of promising drug candidates on the validation network.

Rank	Drug name	Degree centrality
1	Tamoxifen	0.661
2	Doxorubicin	0.554
3	Paclitaxel	0.536
4	Fulvestrant	0.268
5	Methotrexate	0.268
6	Camptothecin	0.232
7	Letrozole	0.214
8	Vinblastine	0.196
9	Exemestane	0.179
10	Megestrol	0.125
11	Aminoglutethimide	0.107
12	MS-275	0.089
13	Alsterpaullone	0.071
14	GW-8510	0.036
15	Phenoxybenzamine	0.036
16	Celastrol	0.036
17	Tyrphostin_AG-825	0.018

Known breast cancer drug. Potential drug candidate for repositioning.