Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis

Table 1

Information of eligible studies included in the meta-analysis.

Author	Year	Country	COPD/control	COPD			Control			COPD		Control		HWE in control
				I/I	I/D	D/D	I/I	I/D	D/D	I	D	I	D
Simsek	2013	Turkey	66/40	15	20	31	8	19	13	50	82	35	45	0.823
Ulasli	2013	Turkey	80/49	16	17	49	6	10	33	49	111	22	76	0.004
Ayada	2014	Turkey	47/64	8	26	13	8	28	28	42	52	44	84	0.808
Ahsan	2004	India	27/66	10	12	5	23	33	10	32	22	79	53	0.743
Gu	2003	China	122/159	28	37	57	49	85	25	93	151	183	135	0.235
Hopkinson	2008	UK	103/101	29	49	25	28	49	24	107	99	105	97	0.777
Jiang	2004	China	30/30	7	12	11	15	10	5	26	34	40	20	0.171
Pabst	2009	German	152/158	43	76	33	39	69	50	162	142	147	169	0.124
Tkáčová	2005	Slovakia	66/118	15	31	20	19	68	31	61	71	106	130	0.074
van Suylen	1999	Netherlands	87/95	17	43	27	17	50	28	77	97	84	106	0.514
Wang	2000	China	20/38	5	7	8	13	18	7	17	23	44	32	0.861
Yildiz	2003	Turkey	42/40	7	21	14	10	18	12	35	49	38	42	0.536
Zhang	2008	China	61/57	21	27	13	20	28	9	69	53	68	46	0.877
Busquets	2007	Spain	74/77	7	40	27	11	53	13	54	94	75	79	<0.001

COPD: chronic obstructive pulmonary disease; ACE: angiotensin-converting enzyme; I/I: insertion/insertion genotype; I/D: insertion/deletion genotype; D/D: deletion/deletion genotype; HWE: Hardy-Weinberg equilibrium.