Altered Expression of EPO Might Underlie Hepatic Hemangiomas in LRRK2 Knockout Mice

Figure 3

Expression of EPO and VEGF in the kidneys of mice at different ages. qRT-PCR analysis of EPO and VEGF mRNA levels in the kidneys of LRRK2^−/− mice at the ages of 2 (a), 12 (b), 18-19 (c), and 22-23 (d) months. EPO expression in the kidneys of 18-19-month-old LRRK2^−/− mice was reduced to ~20% of the wild-type level, which was restored to wild-type levels at the age of 22-23 months. ns, not significant.

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