Silver-Containing Hydroxyapatite Coating Reduces Biofilm Formation by Methicillin-Resistant Staphylococcus aureus In Vitro and In Vivo

Figure 1

Representative fluorescence microscopic images of implants after bacterial culture for 7 and 14 days in vitro. The bar indicates 100 µm. (a) Hydroxyapatite (HA) coating at 7 days, (b) 0.5% silver-containing HA (Ag-HA) coating at 7 days, (c) 1% Ag-HA coating at 7 days, (d) 3% Ag-HA coating at 7 days, (e) HA coating at 14 days, (f) 0.5% Ag-HA coating at 14 days, (g) 1% Ag-HA coating at 14 days, and (h) 3% Ag-HA coating at 14 days. Calculated BCRs: (a) 19.8%, (b) 9.7%, (c) 6.1%, (d) 3.3%, (e) 43.7%, (f) (36.3%), (g) 29.1%, and (h) 8.4%.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)