Silver-Containing Hydroxyapatite Coating Reduces Biofilm Formation by Methicillin-Resistant Staphylococcus aureus In Vitro and In Vivo

Figure 4

Representative fluorescence microscopic images of implants (50x objective) after bacterial infection in vivo. The bar indicates 100 µm. The red coloured areas in the picture correspond to the locations covered by biofilms of methicillin-resistant Staphylococcus aureus (MRSA). (a) HA coating at 1 day, (b) HA coating at 3 days, (c) HA coating at 7 days, (d) 3% Ag-HA coating at 1 day, (e) 3% Ag-HA coating at 3 days, and (f) 3% Ag-HA coating at 7 days. Calculated BCRs: (a) 16.0%, (b) 26.6%, (c) 30.1%, (d) 8.9%, (e) 14.6%, and (f) 13.7%.

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