¹²⁵I Seeds Radiation Induces Paraptosis-Like Cell Death via PI3K/AKT Signaling Pathway in HCT116 Cells

Figure 4

Cytoplasmic vacuoles induced by ¹²⁵I seeds radiation were of ER-origin. HCT 116 cells were exposed to 2 Gy of ¹²⁵I seeds radiation. 48 h later, immunofluorescence analysis was performed to detect mitochondria, ER, and autophagosomes. (a) Immunofluorescence images stained with anti-Calnexin and anti-TIM23 antibody. Cytoplasmic vacuoles were denoted by white arrowheads. (b) Immunofluorescence images stained with anti-LC3 antibody. Cytoplasmic vacuoles were denoted by white arrowheads.

(a)

(b)