Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain

Figure 1

Effects of acute treatment with hesperidin on mechanical and thermal hyperalgesia after inducing CCI in rats. Time course curves show the effect of hesperidin, gabapentin, and vehicle on the withdrawal threshold after mechanical stimulus (a) and on the withdrawal latency after thermal stimulus (b), assessed every 30 minutes over a 2 h period. Each point is the average of withdrawal threshold (g) or withdrawal latency (s) SEM in at least six rats. Two-way ANOVA followed by Tukey’s test, asterisks indicate statistical significance between the vehicle and the treatment groups on the same day: , , and .

(a)

(b)