Antihyperalgesic Effect of Hesperidin Improves with Diosmin in Experimental Neuropathic Pain

Figure 5

Antihyperalgesic effect obtained from the time course curves of the following compounds alone and in presence of the combination DS10/HS100 mg/kg in the CCI model: naloxone (1 mg/kg, i.p.), bicuculline (5 mg/kg, i.p.), haloperidol (0.1 mg/kg, i.p.), and WAY100635 (0.1 mg/kg, s.c.) on the withdrawal threshold at 30 min (a) and 120 min (b) and withdrawal latency at 30 min (c) and 120 min (d). Each column is the average of withdrawal threshold (g) or withdrawal latency (s) ± SEM in at least six rats. Three-way ANOVA followed by Tukey’s test, symbols indicate statistical significance among the DS/HS alone group and the antagonist with DS/HS groups: , , and versus vehicle; versus naloxone, versus bicuculline, and versus WAY100635.

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(b)

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