Prenatal Dexamethasone Exposure Increases the Susceptibility to Autoimmunity in Offspring Rats by Epigenetic Programing of Glucocorticoid Receptor

Figure 2

GR and different exon 1 expression and methylation. (a) mRNA expression of total GR and different exon1 regions, analyzed by Mann–Whitney nonparametric test, . (b) GR protein expression from different groups. Lanes 1 to 3 were from DEX rats, while lanes 4 to 6 were from saline rats. (c) Relative quantitate data for GR protein expression, analyzed by Mann–Whitney nonparametric test, . (d) comparison of methylation levels in exon1s of GR gene between DEX and saline rats, analyzed by Mann–Whitney nonparametric test, .

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