Prediction of Bacillus Calmette-Guerin Response in Patients with Bladder Cancer after Transurethral Resection of Bladder Tumor by Using Genetic Variation Based on Genomic Studies

Table 1

Inflammatory genes.

Study	Sample (number)	Genes	Description
Leibovici et al. [13]	135	IL-6(-74 C/C)	It was associated with a decreased recurrence risk (HR = 0.298; ) and an increased RFS () after BCG
Ahirwar et al. [14]	69	IL-6(-74 C/C)	It was associated with an increased recurrence risk (HR: 4.60) in patients receiving BCG
Lima et al. [6]	204	TNF-a(rs1799964 C/C)	Both of them were associated with a decreased recurrence risk
Ahirwar et al. [15]	73	TNF-a(rs1799964 C/C)
Ahirwar et al. [17]	71	IL-8(rs4073 A/A)	It was associated with a decreased recurrence risk () and an increased RFS ()
Leibovici et al. [13]	135	IL-8(rs4073 A/A)	There was no association
Lima et al. [6]	204	IL4(rs2070874 C/C); TRAILR1(rs79037040 T/T); IL2RA(rs2104286 T/T); IL17RA(rs4819554 A/A)	They were associated with an elevated risk of recurrence
Ahirwar et al. [17]	71	NF-kB(-94ATTGdel/del)
Ahirwar et al. [16]	73	IFN-G(+874 A/A)
		TGF-B(+28 T/T)	It demonstrated protective association