BioMed Research International / 2016 / Article / Tab 2 / Review Article
Prediction of Bacillus Calmette-Guerin Response in Patients with Bladder Cancer after Transurethral Resection of Bladder Tumor by Using Genetic Variation Based on Genomic Studies Table 2 Glutathione (GSH) pathway genes.
Study Sample (number) Genes Description Chiong et al. [21 ] 99 hGPX1(198 C/T) It was associated with an increased recurrence risk (HR = 3.0; ) Kang et al. [23 ] 135 GSTT1-positive It had a higher risk of BCG nonresponsiveness (HR = 14; ) Ke et al. [22 ] 191 GSS(rs7265992 A/A) GSS(rs6060124 A/A) GSS(rs4911455 C/C) GPX2(rs10133290 C/C) GSTM4(rs560018 G/G) They were associated with an elevated risk of recurrence Ke et al. [22 ] 191 GPX5(rs377514 C/C) GSTM3(rs4970737 G/G) They demonstrated protective association