Review Article

Prediction of Bacillus Calmette-Guerin Response in Patients with Bladder Cancer after Transurethral Resection of Bladder Tumor by Using Genetic Variation Based on Genomic Studies

Table 2

Glutathione (GSH) pathway genes.

StudySample (number)GenesDescription

Chiong et al. [21]99hGPX1(198 C/T)It was associated with an increased recurrence risk (HR = 3.0; )
Kang et al. [23]135GSTT1-positiveIt had a higher risk of BCG nonresponsiveness (HR = 14; )
Ke et al. [22]191GSS(rs7265992 A/A)
GSS(rs6060124 A/A)
GSS(rs4911455 C/C)
GPX2(rs10133290 C/C)
GSTM4(rs560018 G/G)
They were associated with an elevated risk of recurrence
Ke et al. [22]191GPX5(rs377514 C/C)
GSTM3(rs4970737 G/G)
They demonstrated protective association