MYC Gene Rearrangements Are Closely Associated with Poor Survival of Diffuse Large B Cell Lymphoma with Hepatitis B Virus Infection

Table 3

Results of the Cox regression to evaluate independent risk factors affecting overall survival of all patients in this study.

Characteristics	Univariable analysis			Multivariable analysis
	HR	95% CI of HR	value	HR	95% CI of HR	value
Sex	1.512	0.613–3.725	0.369
Age (≥60)	0.540	0.233–1.251	0.151
Stage (III/IV)	0.410	0.151–1.113	0.080
IPI (>2)	3.876	1.572–9.524	0.003	4.274	1.721–10.638	0.002
Ki-67 (>80%)	2.036	0.602–6.884	0.252
Molecular subtype	0.605	0.222–1.645	0.325
Rituximab	0.404	0.172–0.949	0.038	0.333	0.135–0.820	0.017
MYC positive	4.274	1.553–11.765	0.005	5.556	1.706–18.182	0.004
BCL2 positive	0.507	0.166–1.545	0.232
HBV status	2.338	1.006–5.432	0.048	1.215	0.487–3.034	0.677

Note. HR, hazard ratio; CI, confidence index; IPI, international prognostic index.