Activity of Fosfomycin- and Daptomycin-Containing Bone Cement on Selected Bacterial Species Being Associated with Orthopedic Infections

Figure 4

Number of samples with the different growth of bacteria in the nutrient broth after incubation with test specimens of 0.5 g (a, d, g, j), 1.0 g (b, e, h, k), and 1.5 g daptomycin (c, f, i, l)/0.5 g gentamicin-containing bone cement. Bacteria (Staphylococcus aureus ATCC 29213 (MSSA; (a), (b), (c)), S. aureus ATCC 44300 (MRSA; (d), (e), (f)), S. epidermidis DSM 8913 (g, h, i), and Enterococcus faecium DSM 13590 (VRE; (j), (k), (l))) were added at the beginning in a concentration of 10³ or 10⁶ to 10 ml of nutrient media. All controls (bone cement without antibiotics) showed confluent growth (not shown).

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(b)

(c)

(d)

(e)

(f)

(g)

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(k)

(l)