Protective Effects of Pyridoxamine Supplementation in the Early Stages of Diet-Induced Kidney Dysfunction

Table 1

Effects of HD and pyridoxamine administration on mouse body and tissue weight and blood chemistry at 12 weeks of dietary manipulation. Values are mean ± SEM. versus SD; versus HD.

	SD	SD + P	HD	HD + P
	()	()	()	()
Body weight (g)	25.4 ± 1.3	26.6 ± 3.0	32.8 ± 1.7	34.7 ± 3.6
Food intake (g/day)	2.25 ± 0.07	2.72 ± 0.12	2.30 ± 0.28	2.40 ± 0.14
Kidney weight (% BW)	1.02 ± 0.08	1.08 ± 0.11	0.94 ± 0.10	1.11 ± 0.18
Blood glucose (mg/dl)	72.8 ± 18.9	61.8 ± 16.2	138.8 ± 12.7	104.6 ± 9.7
Plasma insulin (μg/l)	85.8 ± 5.3	78.1 ± 12.7	106.8 ± 6.8	103.5 ± 11.0
Plasma triglyceride (mg/dl)	37.1 ± 7.6	29.3 ± 5.5	50.5 ± 9.2	34.7 ± 4.7
Plasma cholesterol (mg/dl)	77.2 ± 6.1	84.8 ± 16.4	97.2 ± 8.2	87.2 ± 2.2