Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury

Figure 1

PARP-1 expression was analyzed in nuclear protein lysates using the entire hemisphere of animals exposed to HI followed by vehicle or TES448 treatment. A representative Western blot image shows the expression of PARP-1 at 48 hrs after HI. Data are normalized to sham animals (control = 100%, dashed line). Values are presented as box plots including median values, the 25% and the 75% percentile (, unpaired Student’s -test, = 8–11 per group).