Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="7"><hr/></td></tr><tr class="thead"><td class="align_left"> </td><td class="align_center">Sham + NaCl</td><td class="align_center">Sham + TES448</td><td class="align_center">HI + NaCl</td><td class="align_center">HI + NaCl + HT</td><td class="align_center">HI + TES448</td><td class="align_center">HI + TES448 + HT</td></tr><tr><td class="thead-hr" colspan="7"><hr/></td></tr><tr><td class="align_left">Weight at P10 (g)</td><td class="align_center">20.42 ± 0.5</td><td class="align_center">20.99 ± 0.5</td><td class="align_center">21.08 ± 0.4</td><td class="align_center">24.5 ± 1.0</td><td class="align_center">21.32 ± 0.8</td><td class="align_center">25.6 ± 1.0</td></tr><tr><td class="align_left">Weight at P12 (g)</td><td class="align_center">24.78 ± 0.5</td><td class="align_center">25.42 ± 0.9</td><td class="align_center">21.09 ± 0.6</td><td class="align_center">25.5 ± 1.6</td><td class="align_center">21.82 ± 0.6</td><td class="align_center">26.1 ± 1.4</td></tr><tr><td class="align_left">Gained weight</td><td class="align_center">122%  ± 1.0</td><td class="align_center">122.3%  ± 2.1</td><td class="align_center">100%<svg height="11.5773pt" id="M20" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.5275 5.04606 11.5773" width="5.04606pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z" id="g58-33"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="487" vert-adv-y="487" xpluscharwidth="4.43168539"></glyph.data></g></svg> ± 2.0</td><td class="align_center">104.1%<svg height="11.8239pt" id="M21" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.7741 5.21047 11.8239" width="5.21047pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M458 122C446 142 422 163 404 170C370 149 335 141 272 139V142C272 216 281 255 311 281C280 309 275 350 272 418C335 417 370 407 404 387C422 394 447 415 458 436C447 456 424 477 402 484C370 463 335 455 272 453C276 506 282 532 312 584C297 610 275 636 253 647C232 636 208 610 194 584C223 532 230 506 234 453C171 455 136 463 102 484C84 477 60 456 48 436C60 415 84 393 102 387C136 407 171 417 234 418C231 350 226 309 195 281C226 255 231 214 234 139C171 141 136 149 102 170C84 163 60 142 48 122C60 101 84 79 102 72C136 93 171 103 234 104C230 35 224 8 195 -42C208 -69 232 -94 254 -106C274 -94 298 -69 312 -42C282 8 276 35 272 104C335 103 370 93 404 72C422 79 446 101 458 122Z" id="g50-16"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="505" vert-adv-y="505" xpluscharwidth="4.595484850000001"></glyph.data></g></svg>  ± 4.1</td><td class="align_center">103.4%<svg height="11.5773pt" id="M22" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.5275 5.04606 11.5773" width="5.04606pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z" id="g58-33"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="487" vert-adv-y="487" xpluscharwidth="4.43168539"></glyph.data></g></svg>  ± 2.7</td><td class="align_center">102.3%<svg height="11.5773pt" id="M23" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.5275 5.04606 11.5773" width="5.04606pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M457 455H370L403 612H360L326 455H218L252 612H210L175 455H77L68 394H161L132 257H31L20 196H117L77 19H120L159 196H268L230 19H272L311 196H402L412 257H325L355 394H447L457 455ZM313 394L283 257H175L204 394H313Z" id="g58-33"></path><glyph.data ascent="1007" descent="-369" horiz-adv-x="487" vert-adv-y="487" xpluscharwidth="4.43168539"></glyph.data></g></svg>  ± 4.5</td></tr><tr class="table-tr"><td colspan="7"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

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BioMed Research International

tab1

Table 1

Table 1: Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury 