Transient Receptor Potential Melastatin 2 Negatively Regulates LPS-ATP-Induced Caspase-1-Dependent Pyroptosis of Bone Marrow-Derived Macrophage by Modulating ROS Production

Figure 2

Caspase-1-dependent pyroptosis was increased in TRPM2−/− group compared to WT group. means that TRPM2−/− group compared to WT group; means that LPS + YVAD + ATP compared to LPS + ATP in the same type mice. The percentage of EtBr positive cells was significantly increased in the TRPM2−/− group compared to WT group after LPS plus ATP treatment, but the percentage of EthD-2 positive cells was similar between two groups.

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