Sodium Mercaptoethane Sulfonate Reduces Collagenolytic Degradation and Synergistically Enhances Antimicrobial Durability in an Antibiotic-Loaded Biopolymer Film for Prevention of Surgical-Site Infections

Figure 1

Diagram of M/R + MeSNA film construction: M/R bilayer film is first constructed from a crosslinked core layer (0.5 mm thick) with absorbed M/R (from soaking and evaporative drying) and a meltable (noncrosslinked) M/R containing top layer (0.25 mm thick). M/R + MeSNA trilayer films were constructed by pressure laminating a third crosslinked layer (0.25 mm thick) with absorbed MeSNA to the bottom of the core layer of the bilayer film creating the trilayer construction.