Thermosensitive Chitosan Hydrogels Containing Polymeric Microspheres for Vaginal Drug Delivery
Table 1
The L9(34) orthogonal design for the optimization of spray-dried operation conditions.
Formulation
Factors
Results
DL, %
EE, %
MS A
120
8
400
1 : 5 : 5
6.73 ± 0.51
74.03 ± 5.61
MS B
120
5
500
2 : 5 : 5
9.10 ± 0.71
54.60 ± 4.26
MS C
120
3
600
1 : 2.5 : 5
9.47 ± 0.35
80.50 ± 2.98
MS D
130
8
500
1 : 2.5 : 5
10.92 ± 0.42
92.82 ± 3.57
MS E
130
5
600
1 : 5 : 5
6.80 ± 0.22
74.80 ± 2.42
MS F
130
3
400
2 : 5 : 5
12.33 ± 0.75
73.98 ± 4.50
MS G
140
8
600
2 : 5 : 5
9.19 ± 0.55
55.14 ± 3.30
MS H
140
5
400
1 : 2.5 : 5
9.69 ± 0.50
82.37 ± 4.25
MS I
140
3
500
1 : 5 : 5
8.69 ± 0.49
95.59 ± 5.39
1
8.43
8.94
9.58
7.41
2
10.01
8.53
9.57
10.20
3
9.19
10.16
8.49
10.03
1.58
1.63
1.09
2.79
Important order
The optimum condition DL
,,, and represent four variables, respectively, as follows: inlet temperature, °C; feed pump rate, mL/min; the air-flow rate, L/h; the ratio of TFV/BSP/CTS (W/W/W); show the relationship between the factors and the value of DL; was used to determine the important order of experiment factors on the values of DL by means of range analysis.
