Markers of Alzheimer’s Disease in Primary Visual Cortex in Normal Aging in Mice

Figure 3

Double IF assays to evaluate the overexpression and changes in the localization of presenilin-2. Observe the increase of PS2 expression and the change in the localization of this enzyme in aged mice (25 M, white arrows). In young mice, PS2 presents a cytoplasmic expression pattern, but, in aged mice (25 M), it is apparently located in the cell membrane (white arrows). Scale bar: 100 µm.