Prediction of Radix Astragali Immunomodulatory Effect of CD80 Expression from Chromatograms by Quantitative Pattern-Activity Relationship

Table 4

The changes of CD80 expression related to % changes of chromatogram regions with different correlation coefficients.

Chromatogram region	Correlation coefficient generated by the prediction algorithm based on		% changes in CD80 expression when chromatogram region intensity (quantity of corresponding compound) was increased by 50, 100, or 200%
	PLS	EN-PLS	PLS			EN-PLS
			50% increase	100% increase	200% increase	50% increase	100% increase	200% increase
1	8.08	12.76	0.42	0.83	2.91	0.38	0.76	2.66
2	−10.59	−10.92	−0.98	−1.95	−3.90	−0.50	−1.01	−2.01
3	11.85	33.57	18.47	36.93	73.87	31.75	63.51	127.02
4	−9.07	−93.96	−1.19	−2.38	−4.76	−6.93	−13.86	−27.72
5	−10.29	−9.32	−0.14	−0.27	0.54	−0.06	−0.12	−0.25
6	9.07	30.64	0.14	0.28	0.56	0.23	0.47	0.93
7	−12.66	−55.19	−1.41	−2.82	−5.64	−3.30	−6.59	−13.18
8	−13.81	−56.59	−6.53	−13.05	−26.10	−14.00	−28.00	−56.00
9	10.63	41.34	0.62	1.25	2.50	1.34	2.68	5.36
10	12.19	48.64	0.15	0.31	0.61	0.34	0.68	1.37
11	−10.78	−30.46	−0.17	−0.35	−0.70	−0.24	−0.48	−0.95
12	0	0	0	0	0	0	0	0
13	0	0	0	0	0	0	0	0