Protective Effects of the Segmental Renal Artery Clamping Technique on Ischemia-Reperfusion Injury in db/db Diabetic Mice

Figure 4

SRAC reveals protective effects on glomeruli and proximal tubule against renal I/R injury in db/db diabetic mice. Representative sections from different groups were fetched 24 h after surgery for histological examination (HE stained, magnification ×400). No obvious histological alternations are found in sham group mice (a, e). Kidneys in nonischemic area of SRAC group are characterized by mild tubular dilatation containing a few exfoliated cells (d, h), while proximal tubule cell necrosis, vacuolization, tubular dilatation, and intratubular exfoliated cells are founded in ischemic area (c, g). Kidneys from RAC group mice show the worst disrupted cytoarchitecture with cavity expansion of glomeruli, greater amount of exfoliated intratubular cells, and cylinders in proximal and collecting tubules (b, f). Given GSE or not has a similar pattern between different-treated groups in our experiment.