BioMed Research International / 2017 / Article / Tab 3 / Review Article
miRNAs in Prediction of Prognosis in Clear Cell Renal Cell Carcinoma Table 3 Studies on combined miRNAs predicting the prognosis of ccRCC.
Sources Combination Ref Findings Clinical miR-21 miR-126 [30 ] Improving sensitivity and specificity in predicting CSS miR-21 miR10b [31 ] The ratio of miR-21/miR10b is associated with tumour nuclear grade, TNM stage, and survival; the ratio is an independent prognostic factor in metastasis-free patients miR-21 miR-126 miR-221 [33 ] The specificity of CRS for high risk patients is 90%, while for the low-risk patients it is 87% miR-125b and TNM stage [16 ] Markedly improving prognostic accuracy Cell and Clinical miR-141-3p miR-145-5p [32 ] Cooperative effect on migration and regulation of HS6ST2 and LOX, of which the latter is a strong prognostic factor for OS
ccRCC, clear cell renal cell carcinoma; CSS, cancer-specific survival; CRD, cancer related death; CRS, combined risk score; TT, tumor thrombus; OS, overall survival; DFS, disease-free survival; ND, no data; TNM, tumor-node-metastasis.