Physicochemical and Biological Characterization of the Proposed Biosimilar Tocilizumab

Table 4

Affinity constants () for binding to sIL-6R, FcγRIIIa, and FcRn receptors as determined by Biacore SPR.

	Originator tocilizumab	HS628
sIL-6R	1.08~1.78 nM	0.92~1.17 nM
FcγRIIIa	0.21~0.38 μM	0.24~0.25 μM
FcRn	0.29~0.31 μM	0.25~0.26 μM