Serum Amyloid A Induces a Vascular Smooth Muscle Cell Phenotype Switch through the p38 MAPK Signaling Pathway

Figure 2

SAA promotes RASMCs toward a synthetic phenotype. The RASMCs were treated with SAA at indicated concentrations for 72 h. (a) mRNA expression of the matrix synthesis related gene was examined by qPCR analysis. (b) Expression of matrix synthesis related markers was detected by Western blot analysis. (c) The proliferative capacity was accessed by thymidine uptake. (d) The migratory capacity was accessed by the migration assay. , versus the control group. Data shown are means ± SD from three independent experiments.

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